Crystal structure of (E)-2-benzylidene-4-[(3-phenyl-4,5-dihydroisoxazol-5-yl)methyl]-2H-benzo[b][1,4]thiazin-3(4H)-one
نویسندگان
چکیده
In the title compound, C25H20N2O2S, the di-hydro-isoxazole ring exhibits an envelope conformation with the methine atom being the flap, while the 1,4-thia-zine ring displays a screw-boat conformation. The six-membered ring fused to the 1,4-thia-zine ring makes dihedral angles of 63.04 (2) and 54.7 (2)° with the mean planes through the five-membered heterocycle and the attached phenyl ring, respectively. The phenyl group connected to the 1,4-thia-zine ring is disordered over two sites [major component = 0.57 (2)]. The most prominent inter-actions in the crystal structure are C-H⋯O hydrogen bonds that link mol-ecules, forming inversion dimers, and C-H⋯N hydrogen bonds that link the dimers into columns parallel to the b axis.
منابع مشابه
Crystal structure of (Z)-2-benzylidene-4-methyl-2H-benzo[b][1,4]thiazin-3(4H)-one
In the title compound, C16H13NOS, the 1,4-thia-zine ring displays a screw-boat conformation. The conformation about the ethene bond [1.344 (2) Å] is Z. The plane of the fused benzene ring makes a dihedral angle of 58.95 (9)° with the pendent phenyl ring, indicating a twisted conformation in the mol-ecule. In the crystal, mol-ecules are linked by pairs of C-H⋯O hydrogen bonds, forming inversion ...
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In the title compound, C15H13NOS, the thia-zine ring adopts a twisted boat conformation and the dihedral angle between the aromatic rings is 86.54 (4)°. In the crystal, mol-ecules are linked by weak C-H⋯O inter-actions, resulting in chains along [010].
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The title compound, C22H20N4O3S, features two fused six-membered rings linked to a 1,2,3-triazole ring which is attached to an ethyl acetate group. The heterocycle in the benzo-thia-zine residue has an envelope conformation with the S atom being the flap. The conformation of the ethyl acetate side chain, which is directed to the same side of the mol-ecule as the C6 ring of the fused-ring system...
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The mol-ecule of the title compound, C18H13NOS, is build up from two fused six-membered rings, with the heterocyclic component linked to a benzyl-idene group and to a prop-2-yn-1-yl chain. The six-membered heterocycle adopts a distorted screw-boat conformation. The prop-2-yn-1-yl chain is almost perpendicular to the mean plane through benzo-thia-zine as indicated by the C-N-C-C torsion angle of...
متن کاملSynthesis and biological studies of triazolo-/thiadiazolo-benzoxazines.
Diethyl bromomalonate (2) with an equimolar amount of 2-aminophenol (1) in the presence of sodium fluoride undergoes a cyclization reaction to form 2H,4H-2-ethoxycarbonyl-3,4-dihydro-3-oxo-1,4-benzoxazine (3). Furthermore, compound 3 undergoes a condensation reaction with hydrazine hydrate in the presence of methanol to yield 2H,4H-2-hydrazinocarbonyl-3,4-dihydro-3-oxo-1,4-benzoxazine (4), whic...
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عنوان ژورنال:
دوره 71 شماره
صفحات -
تاریخ انتشار 2015